Open AccessRole of antioxidants in the treatment of gastroesophageal reflux disease-associated idiopathic pulmonary fibrosis
Author(s) -
Lauryelkine,
Misha F. Vrolijk,
Marjolein Drent,
Aalt Bast
Publication year - 2020
Publication title -
current opinion in pulmonary medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.937
H-Index - 75
eISSN - 1531-6971
pISSN - 1070-5287
DOI - 10.1097/mcp.0000000000000684
Subject(s) - medicine , gerd , idiopathic pulmonary fibrosis , disease , oxidative stress , gastroenterology , intensive care medicine , lung , reflux
Idiopathic pulmonary fibrosis (IPF) is a terminal lung disease of largely unknown cause. Gastroesophageal reflux disease (GERD) was recently discovered to be a trigger for the development of IPF. The current pharmaceutical approach to IPF falls short and there is a pressing need for improved therapeutic options. The present review describes the currently available knowledge regarding the role of oxidative stress and inflammation in the pathophysiology of IPF and GERD and determines the potential use of antioxidants as a treatment option for GERD-associated IPF.