Open AccessDisease phenotyping in chronic obstructive pulmonary disease
Author(s) -
Derek W. Russell,
James M. Wells,
J. Edwin Blalock
Publication year - 2016
Publication title -
current opinion in pulmonary medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.937
H-Index - 75
eISSN - 1531-6971
pISSN - 1070-5287
DOI - 10.1097/mcp.0000000000000238
Subject(s) - medicine , endotype , copd , disease , intensive care medicine , pulmonary disease , chronic bronchitis , exacerbation , immunology , pathology
Despite decades of scientific attention, chronic obstructive pulmonary disease (COPD) remains a major cause of both morbidity and mortality worldwide with strikingly few effective drug classes available. This may be in part because COPD is actually a syndrome composed of distinct diseases with varying pathophysiology (endotypes), and therapies have not been designed to target the causal pathological processes specific to an endotype.