Open AccessMechanisms of REM sleep in health and disease
Author(s) -
Jimmy J. Fraigne,
Kevin P. Grace,
Richard L. Horner,
John Peever
Publication year - 2014
Publication title -
current opinion in pulmonary medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.937
H-Index - 75
eISSN - 1531-6971
pISSN - 1070-5287
DOI - 10.1097/mcp.0000000000000103
Subject(s) - non rapid eye movement sleep , rem sleep behavior disorder , sleep (system call) , medicine , narcolepsy , sleep paralysis , neuroscience , neuroscience of sleep , sleep spindle , cataplexy , rapid eye movement sleep , neurology , polysomnography , psychology , eye movement , apnea , psychiatry , computer science , operating system
Our understanding of rapid eye movement (REM) sleep and how it is generated remains a topic of debate. Understanding REM sleep mechanisms is important because several sleep disorders result from disturbances in the neural circuits that control REM sleep and its characteristics. This review highlights recent work concerning how the central nervous system regulates REM sleep, and how the make up and breakdown of these REM sleep-generating circuits contribute to narcolepsy, REM sleep behaviour disorder and sleep apnea.