Open AccessPhytochemicals suppress nuclear factor-κB signaling
Author(s) -
Antero Salminen,
Anu Kauppinen,
Kai Kaarniranta
Publication year - 2012
Publication title -
current opinion in clinical nutrition and metabolic care
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.21
H-Index - 111
eISSN - 1473-6519
pISSN - 1363-1950
DOI - 10.1097/mco.0b013e32834d3ae7
Subject(s) - signal transduction , inflammation , drug discovery , biology , cancer , nf κb , pharmacology , medicine , bioinformatics , microbiology and biotechnology , immunology , genetics
We will briefly review the current knowledge on the major molecular targets of plant-derived phytochemicals, particularly their connections to nuclear factor-κB (NF-κB) signaling, and accordingly link these observations to their anti-inflammatory properties and beneficial effects on the aging process and age-related degenerative diseases.