Open AccessPhosphatases of regenerating liver are key regulators of metabolism in cancer cells – role of Serine/Glycine metabolism
Author(s) -
Pegah Abdollahi,
Esten N. Vandsemb,
Magne Børset
Publication year - 2021
Publication title -
current opinion in clinical nutrition and metabolic care
Language(s) - English
Resource type - Journals
eISSN - 1473-6519
pISSN - 1363-1950
DOI - 10.1097/mco.0000000000000797
Subject(s) - citric acid cycle , glycolysis , phosphatase , biochemistry , kinase , biology , serine , metabolic pathway , metabolism , cancer cell , microbiology and biotechnology , enzyme , cancer , genetics
Phosphatases of regenerating liver (PRL) are dual-specificity phosphatases and comprise three members, PRL-1, -2 and -3. Despite the importance of PRLs as oncoproteins, there is no consensus function for this family of phosphatases. In the current review paper, we summarize recent findings on the role of PRLs in metabolic regulation.