Open AccessFrom bench to bedside: updates in basic science, translational and clinical research on muscle fatigue in cancer cachexia
Author(s) -
Katherine M. Jackson,
Calvin Cole,
Richard F. Dunne
Publication year - 2021
Publication title -
current opinion in clinical nutrition and metabolic care
Language(s) - English
Resource type - Journals
eISSN - 1473-6519
pISSN - 1363-1950
DOI - 10.1097/mco.0000000000000738
Subject(s) - bench to bedside , cachexia , translational research , medicine , cancer cachexia , translational science , cancer , bioinformatics , intensive care medicine , physical medicine and rehabilitation , pathology , biology , medical physics
Cancer cachexia is a syndrome of loss of weight and muscle mass that leads to reduced strength, poor physical performance and functional impairment. Muscular fatigue is a distressing syndrome that patients with cachexia suffer from and can impair quality of life. Here, we review recent updates in muscular fatigue in cancer cachexia research with a focus on mechanisms, biomarkers and potential therapies.