Open AccessComparative Effectiveness and Safety of Polyethylene Glycol Electrolyte Solution Versus Lactulose for Treatment of Hepatic Encephalopathy
Author(s) -
Mengting Li,
Zhijie Zhang,
Chunming Qiao,
Xiaoling Zhou,
Diankui Shui,
Jiean Huang
Publication year - 2021
Publication title -
journal of clinical gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.141
H-Index - 112
eISSN - 1539-2031
pISSN - 0192-0790
DOI - 10.1097/mcg.0000000000001621
Subject(s) - lactulose , medicine , hepatic encephalopathy , relative risk , confidence interval , meta analysis , adverse effect , peg ratio , randomized controlled trial , gastroenterology , cirrhosis , surgery , finance , economics
Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome associated with liver failure and/or portal systemic shunting. Polyethylene glycol (PEG) electrolyte solution is a commonly used for catharsis of gut, which has been demonstrated to relieve HE in a number of randomized controlled trials. The aim of this paper was to evaluate the comparative efficacy and safety of PEG with lactulose for current HE treatment.