Open AccessEfficacy and Safety of Modified Dual Therapy as the First-line Regimen for the Treatment of Helicobacter pylori Infection
Author(s) -
Quan Huang,
Zhijun Shi,
Hong Cheng,
Hui Ye,
Xuezhi Zhang
Publication year - 2020
Publication title -
journal of clinical gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.141
H-Index - 112
eISSN - 1539-2031
pISSN - 0192-0790
DOI - 10.1097/mcg.0000000000001448
Subject(s) - medicine , regimen , helicobacter pylori , subgroup analysis , amoxicillin , relative risk , cochrane library , clarithromycin , intention to treat analysis , meta analysis , randomized controlled trial , confidence interval , guideline , pharmacotherapy , gastroenterology , antibiotics , pathology , microbiology and biotechnology , biology
In an era of antibiotic resistance, modified dual therapy has been paid much attention because of simple drug composition and low resistance of amoxicillin. However, its eradication rate as a first-line regimen remains controversial. This study is to evaluate the efficacy and safety of modified dual therapy for the initial treatment of Helicobacter pylori (H. pylori) infection compared with mainstream first-line therapies.