Open AccessHaptoglobin 2 Allele is Associated With Histologic Response to Vitamin E in Subjects With Nonalcoholic Steatohepatitis
Author(s) -
Bubu A. Banini,
Sophie C. Cazanave,
Katherine P. Yates,
Amon Asgharpour,
Robert Vincent,
Faridoddin Mirshahi,
Peter Le,
Melissa J. Contos,
James Tonascia,
Naga Chalasani,
Kris V. Kowdley,
Arthur J. McCullough,
Cynthia Behling,
Jeffrey B. Schwimmer,
Joel E. Lavine,
Arun J. Sanyal
Publication year - 2019
Publication title -
journal of clinical gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.141
H-Index - 112
eISSN - 1539-2031
pISSN - 0192-0790
DOI - 10.1097/mcg.0000000000001142
Subject(s) - medicine , vitamin e , nonalcoholic fatty liver disease , gastroenterology , haptoglobin , placebo , steatohepatitis , fatty liver , alkaline phosphatase , nonalcoholic steatohepatitis , endocrinology , pathology , disease , antioxidant , biology , enzyme , biochemistry , alternative medicine
Haptoglobin (Hp) genotype has been linked to oxidative stress and cardiovascular outcomes in response to vitamin E (VitE) among patients with diabetes mellitus. Its effect on histologic response to VitE in nonalcoholic steatohepatitis (NASH) is unknown.