Open AccessIntermittent feeding and circadian rhythm in critical illness
Author(s) -
Imre W. K. Kouw,
Leonie K. Heilbronn,
Arthur R.H. van Zanten
Publication year - 2022
Publication title -
current opinion in critical care, with evaluated medline/current opinion in critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.212
H-Index - 88
eISSN - 1080-8183
pISSN - 1070-5295
DOI - 10.1097/mcc.0000000000000960
Subject(s) - circadian rhythm , medicine , enteral administration , circadian clock , rhythm , light effects on circadian rhythm , entrainment (biomusicology) , bacterial circadian rhythms , physiology , endocrinology , parenteral nutrition
Circadian rhythms, i.e., periodic oscillations in internal biological processes, modulate metabolic processes such as hormonal signalling, nutrient absorption, and xenobiotic detoxification. Meal timing is a strong entraining cue for peripheral clocks in various organs, and eating out of circadian phases can impair glucose, gastrointestinal, and muscle metabolism. Sleep/wake cycles and circadian rhythms are extremely disrupted during critical illness. Timing of nutritional support may help preserve circadian rhythms and improve post-Intensive Care Unit (ICU) recovery. This review summarises circadian disruptors during ICU admission and evaluates the potential benefits of intermittent feeding on metabolism and circadian rhythms.