Open AccessThe liver-gut-axis: initiator and responder to sepsis
Author(s) -
Michael Bauer
Publication year - 2022
Publication title -
current opinion in critical care, with evaluated medline/current opinion in critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.212
H-Index - 88
eISSN - 1080-8183
pISSN - 1070-5295
DOI - 10.1097/mcc.0000000000000921
Subject(s) - sepsis , medicine , gut flora , microbiome , crosstalk , dysbiosis , gut microbiome , immunology , bioinformatics , biology , physics , optics
The 'gut-liver axis' is thought to play an important role in pathogenesis of sepsis. Despite a wealth of experimental data to support the concept of reciprocal crosstalk between gut and liver through bacterial translocation and shaping of the microbiome by liver-derived molecules, for example bile acids, clinical data, and in particular diagnostic and therapeutic options, are limited.