Open AccessDiagnosis and treatment of intracranial hemorrhage in children with hemophilia
Author(s) -
Kim Nagel,
Mohan Pai,
Bosco Paes,
Anthony Chan
Publication year - 2013
Publication title -
blood coagulation and fibrinolysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.376
H-Index - 71
eISSN - 1473-5733
pISSN - 0957-5235
DOI - 10.1097/mbc.0b013e32835975d6
Subject(s) - medicine , randomized controlled trial , medline , presentation (obstetrics) , incidence (geometry) , pediatrics , intensive care medicine , complication , surgery , physics , political science , law , optics
Intracranial hemorrhage (ICH) is a significant complication for children with hemophilia. Identifying risk factors may allow us to establish clinically relevant guidelines for the diagnosis and management of ICH. The purpose of this review is to nucleate evidence from the available literature on the incidence, risk factors, presentation, treatment, and outcomes of ICH that can be utilized to develop a clinically useful framework for the diagnosis and management of hemophiliac patients with the condition. An electronic MEDLINE and EMBASE literature search was undertaken using the key words 'intracranial hemorrhage and hemophilia' and setting limits as: Last 10 years and Review or Randomized Controlled Trial (RCT) or Clinical Trial, or Practice Guidelines. Following review of all articles using predetermined search words and criteria, 31 were retrieved with sufficient data to address our objectives. An algorithm is presented for the management of children (≥3 years-18 years) with hemophilia and suspected ICH. A standardized approach to ICH may reduce unnecessary exposure to radiation via computed tomography scan in a select group of children. Currently there is limited scientific evidence to recommend a diagnostic and therapeutic algorithm for neonates with hemophilia.