Open AccessIn Vivo Evaluation of a New Surfactant Polymer Coating Mimicking the Glycocalyx of Endothelial Cells
Author(s) -
Akira Shiose,
Tohru Takaseya,
Hyun Il Kim,
Mariko Kobayashi,
Tetsuya Horai,
Subramanyeshwar Rao,
Yoko Arakawa,
Masako Fujiki,
Mark A. McCarthy,
Yubiao Liu,
Jan Lewandowski,
Anne Sally Davis,
Kiyotaka Fukamachi
Publication year - 2011
Publication title -
asaio journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.961
H-Index - 66
eISSN - 1538-943X
pISSN - 1058-2916
DOI - 10.1097/mat.0b013e318229ac9c
Subject(s) - oxygenator , cardiopulmonary bypass , hemodynamics , coating , biomedical engineering , heparin , chemistry , medicine , anesthesia , materials science , surgery , composite material
The purpose of this study was to demonstrate that a proprietary surfactant polymer (SP) coating does not adversely affect the hemodynamic performance of cardiopulmonary bypass (CPB) or gas exchange in oxygenators. The new coating was applied to a CPB circuit including cannulae, reservoir, oxygenator, and blood pump implanted into 12 pigs, divided into groups with either coated or noncoated pumps. CPB flow was maintained at a fixed level of approximately 2.4 L/min for 6 hours with full heparinization. Hemodynamic data and pump performance were recorded every hour, and blood samples were taken every 2 hours. After sacrifice, the CPB circuit and major organs were macroscopically examined. There was no significant difference in the oxygen transfer rate between the two groups. The coating did not adversely affect oxygenator inlet or outlet pressures. There was no significant difference between the two groups in microthrombi seen in the oxygenators. No thromboemboli were noted in the major organs on gross or histologic examination. In conclusion, this new SP coating did not decrease gas exchange performance, and its biocompatibility evaluations revealed no differences between coated and noncoated groups under aggressive heparin use.