Open AccessThe Current Status of Bioartificial Pancreas Devices
Author(s) -
Sara J Photiadis,
Rebecca Gologorsky,
Deepika Sarode
Publication year - 2020
Publication title -
asaio journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.961
H-Index - 66
eISSN - 1538-943X
pISSN - 1058-2916
DOI - 10.1097/mat.0000000000001252
Subject(s) - medicine , immunosuppression , pancreas , pancreas transplantation , endocrine system , diabetes mellitus , artificial pancreas , transplantation , type 1 diabetes , insulin , islet , islet cell transplantation , intensive care medicine , endocrinology , hormone , kidney transplantation
Type 1 diabetes mellitus is a common and highly morbid disease for which there is no cure. Treatment primarily involves exogenous insulin administration, and, under specific circumstances, islet or pancreas transplantation. However, insulin replacement alone fails to replicate the endocrine function of the pancreas and does not provide durable euglycemia. In addition, transplantation requires lifelong use of immunosuppressive medications, which has deleterious side effects, is expensive, and is inappropriate for use in adolescents. A bioartificial pancreas that provides total endocrine pancreatic function without immunosuppression is a potential therapy for treatment of type 1 diabetes. Numerous models are in development and take different approaches to cell source, encapsulation method, and device implantation location. We review current therapies for type 1 diabetes mellitus, the requirements for a bioartificial pancreas, and quantitatively compare device function.