Open AccessDel Nido Cardioplegia for Myocardial Protection in Adult Cardiac Surgery: A Systematic Review and Meta-Analysis
Author(s) -
Yongnan Li,
Hao Lin,
Yajing Zhao,
Zhenzhen Li,
Debin Liu,
Xiangyang Wu,
Bingyang Ji,
Bingren Gao
Publication year - 2018
Publication title -
asaio journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.961
H-Index - 66
eISSN - 1538-943X
pISSN - 1058-2916
DOI - 10.1097/mat.0000000000000652
Subject(s) - medicine , inotrope , confidence interval , cochrane library , cardiopulmonary bypass , cardiac surgery , intensive care unit , meta analysis , atrial fibrillation , cardiology , mechanical ventilation , anesthesia
Cardioplegia is an important strategy for myocardial protection during cardiac surgery. This meta-analysis was to compare the effects of del Nido and conventional cardioplegia in adult patients. Systematic searches were performed to identify studies using PubMed, Embase, the Cochrane Library, and the International Clinical Trials Registry Platform. A total of nine studies were included. Cardiopulmonary bypass and cross-clamp time were significantly shorter in the del Nido than conventional cardioplegia (mean difference [MD]: -7.52, 95% confidence interval [95% CI]: -14.76 to -0.29, p = 0.04; MD: -5.74, 95% CI: -10.14 to -1.34, p = 0.01). During the operation, cardioplegia volume and blood glucose level were lower in the del Nido group (MD: -522.53, 95% CI: -926.68 to -118.37, p = 0.01; standardized mean difference [SMD]: -1.11, 95% CI: -1.74 to -0.48, p = 0.0006). Ventilation time and length of intensive care unit were decreased significantly with del Nido cardioplegia (MD: -1.05, 95% CI: -1.79 to -0.31, p = 0.006; MD: -0.65, 95% CI: -0.92 to -0.38, p < 0.00001). There were no differences in myocardial enzyme, postoperative inotropic support, atrial fibrillation, hospital, and mortality between the two groups. In adult cardiac surgery, myocardial protection used with the del Nido or conventional cardioplegia solution yield similar short-term clinical outcomes.