Open AccessSpironolactone Ameliorates Cochlear Implant Induced Endolymphatic Hydrops
Author(s) -
Nathan Creber,
Hayden Eastwood,
Amy Hampson,
Jonathon Lo,
Dongcheng Zhang,
Scott Chambers,
Christofer Bester,
Peter R. Thorne,
Stephen O’Leary
Publication year - 2022
Publication title -
otology and neurotology
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1537-4505
pISSN - 1531-7129
DOI - 10.1097/mao.0000000000003517
Subject(s) - medicine , electrocochleography , spironolactone , endolymphatic hydrops , implant , compound muscle action potential , cochlear implant , electrophysiology , cochlear implantation , round window , mineralocorticoid receptor , inner ear , mineralocorticoid , endocochlear potential , hearing loss , guinea pig , surgery , audiology , anatomy , meniere's disease , receptor , heart failure , disease
Endolymphatic hydrops (EH) has been observed in both animal and human cochleae following cochlear implant (CI) surgery. We tested whether EH could be eliminated by administration of mineralocorticoid steroid antagonist spironolactone and explored the electrophysiological consequences of this.