Open AccessGenomics, Epigenetics, and Hearing Loss in Neurofibromatosis Type 2
Author(s) -
Christine T. Dinh,
Eric Nisenbaum,
Darius Chyou,
Carly Misztal,
Denise Yan,
Rahul Mittal,
Juan I. Young,
Mustafa Tekin,
Fred F. Telischi,
Cristina FernándezValle,
Xuezhong Liu
Publication year - 2020
Publication title -
otology and neurotology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.147
H-Index - 104
eISSN - 1537-4505
pISSN - 1531-7129
DOI - 10.1097/mao.0000000000002613
Subject(s) - epigenetics , hearing loss , neurofibromatosis type 2 , medicine , genetics , neurofibromatosis , bioinformatics , audiology , biology , gene
In this review, we discuss current knowledge about the genetics and epigenetics of vestibular schwannoma (VS) in relation to hearing loss. A multistep and sequential genetic algorithm suitable for the identification of Neurofibromatosis Type 2 (NF2) constitutional and somatic mutations is discussed.