Open AccessHigh Expression of Circular RNA–Mitochondrial tRNA Translation Optimization 1 Assists the Diagnosis of High-Risk Human Papillomavirus Infection in Cervical Cancer
Author(s) -
Xiyun Cheng,
Changmei Shen,
Zhenrong Liao
Publication year - 2022
Publication title -
journal of lower genital tract disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 43
eISSN - 1526-0976
pISSN - 1089-2591
DOI - 10.1097/lgt.0000000000000675
Subject(s) - medicine , hpv infection , human papillomavirus , cervical cancer , oncology , receiver operating characteristic , cancer , metastasis , microrna , viral load , gastroenterology , virus , immunology , gene , biology , biochemistry
Persistence of high-risk human papillomavirus (HR-HPV) infection is a paramount determinant in cervical cancer (CC) development. Circular RNAs have the potential to be promising biomarkers for various cancers. This study explored circular RNA-mitochondrial tRNA translation optimization 1 (circMTO1) expression in the serum of CC patients and its clinical value in diagnosing CC and predicting HR-HPV infection.