Open AccessIntravesical Instillation of OnabotulinumtoxinA in the Treatment of Refractory Overactive Bladder in Participants with Urinary Incontinence
Author(s) -
Christopher Chermansky,
Holly E. Richter,
Karny Jacoby,
Wilson Titanji,
Brenda Jenkins,
Till Geib,
Benjamin Brucker
Publication year - 2022
Publication title -
the journal of urology/the journal of urology
Language(s) - English
Resource type - Journals
eISSN - 1527-3792
pISSN - 0022-5347
DOI - 10.1097/ju.0000000000002800
Subject(s) - medicine , overactive bladder , nocturia , urology , urination , urinary incontinence , placebo , adverse effect , urinary system , urinary bladder , alternative medicine , pathology
Intradetrusor injections of onabotulinumtoxinA are efficacious for the treatment of overactive bladder with urgency urinary incontinence in adults refractory to or intolerant of anticholinergics. Delivery of onabotulinumtoxinA via instillation would reduce the need for intradetrusor injections. The objective of this trial was to assess the efficacy and safety of intravesical instillation of an onabotulinumtoxinA + hydrogel admixture.