Open AccessHeterogeneity in Genomic Risk Assessment from Tissue Based Prognostic Signatures Used in the Biopsy Setting and the Impact of Magnetic Resonance Imaging Targeted Biopsy
Author(s) -
Sanoj Punnen,
Radka Stoyanova,
Deukwoo Kwon,
Isildinha M. Reis,
Nachiketh SoodanaPrakash,
Chad R. Ritch,
Bruno Nahar,
Mark L. Gonzalgo,
Bruce Kava,
Yang Liu,
Himanshu Arora,
Sandra M. Gaston,
Rosa P. Castillo Acosta,
Alan Dal Pra,
Matthew C. Abramowitz,
Oleksandr N. Kryvenko,
Elai Davicioni,
Alan Pollack,
Dipen J. Parekh
Publication year - 2021
Publication title -
the journal of urology/the journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.402
H-Index - 256
eISSN - 1527-3792
pISSN - 0022-5347
DOI - 10.1097/ju.0000000000001559
Subject(s) - biopsy , magnetic resonance imaging , medicine , prostate cancer , radiology , prostate biopsy , cancer , oncology
Genomic prognostic signatures are used on prostate biopsy tissue for cancer risk assessment, but tumor heterogeneity and multifocality may be an issue. We evaluated the variability in genomic risk assessment from different biopsy cores within the prostate using 3 prognostic signatures (Decipher, CCP, GPS).