Open AccessPrespecified 4-Kallikrein Marker Model at Age 50 or 60 for Early Detection of Lethal Prostate Cancer in a Large Population Based Cohort of Asymptomatic Men Followed for 20 Years
Author(s) -
Emily Vertosick,
Christel Häggström,
Daniel D. Sjoberg,
Göran Hallmans,
Robert Johansson,
Andrew Vickers,
Pär Stattin,
Hans Lilja
Publication year - 2020
Publication title -
the journal of urology/the journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.402
H-Index - 256
eISSN - 1527-3792
pISSN - 0022-5347
DOI - 10.1097/ju.0000000000001007
Subject(s) - prostate cancer , medicine , prostate specific antigen , cancer , population , oncology , prostate , cohort , gynecology , environmental health
A prespecified statistical model based on 4 kallikrein markers in blood, commercially available as the 4Kscore®, has been shown to accurately detect high grade (greater than Grade Group 2) prostate cancer in men with moderately elevated prostate specific antigen. We assessed whether the model predicted prostate cancer metastasis or death in men not subject to prostate specific antigen screening.