Open AccessClinical Response to PI3K-α Inhibition in a Cohort of Children and Adults With PIK3CA-Related Overgrowth Spectrum Disorders
Author(s) -
Prashant Raghavendran,
Sharon E. Albers,
James D. Phillips,
Sara ZarnegarLumley,
Alexandra J. Borst
Publication year - 2022
Publication title -
journal of vascular anomalies
Language(s) - English
Resource type - Journals
ISSN - 2690-2702
DOI - 10.1097/jova.0000000000000038
Subject(s) - medicine , clinical trial , cohort , broad spectrum , multidisciplinary approach , pediatrics , quality of life (healthcare) , intensive care medicine , social science , chemistry , sociology , combinatorial chemistry , nursing
The goal of this report is to describe, through a series of 5 cases, the clinical response and safety of alpelisib (BYL719) use in children and adults with PIK3CA -related overgrowth spectrum (PROS) disorders at our center.