Open AccessAtherogenic Diet Accelerates Ectopic Mineralization in a Mouse Model of Pseudoxanthoma Elasticum
Author(s) -
Jingyi Zhao,
Joshua Kingman,
Ida Joely Jacobs,
Jouni Uitto,
Yi Cao,
Qiaoli Li
Publication year - 2020
Publication title -
international journal of dermatology and venereology
Language(s) - English
Resource type - Journals
eISSN - 2641-8746
pISSN - 2096-5540
DOI - 10.1097/jd9.0000000000000086
Subject(s) - pseudoxanthoma elasticum , mineralization (soil science) , chemistry , medicine , pathology , organic chemistry , nitrogen
Pseudoxanthoma elasticum (PXE) is a multisystem heritable disorder caused by mutations in the Abcc6 gene. The disease is characterized by ectopic mineralization of the skin, eyes, and arterial blood vessels. Previous studies have suggested that cardiovascular complications in patients with PXE are caused in part by premature atherosclerosis. The aim of this study is to determine the effect of an atherogenic diet on ectopic mineralization.