Open AccessReporting Patterns of Sialorrhea Comparing Users of Clozapine to Users of Other Antipsychotics
Author(s) -
Wai Hong Man,
Ingeborg Wilting,
Patrick C. Souverein,
R Meyboom,
Toine C. G. Egberts,
Eibert R. Heerdink
Publication year - 2020
Publication title -
journal of clinical psychopharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.786
H-Index - 121
eISSN - 1533-712X
pISSN - 0271-0749
DOI - 10.1097/jcp.0000000000001198
Subject(s) - sialorrhea , clozapine , odds ratio , medicine , confidence interval , antipsychotic , schizophrenia (object oriented programming) , adverse drug reaction , logistic regression , psychiatry , drug , pediatrics , anesthesia
Sialorrhea is a non-life-threatening, but potentially invalidating adverse drug reaction (ADR) in patients using clozapine. In light of the very serious ADRs (agranulocytosis and myocarditis), sialorrhea is at risk to be overlooked by health care professionals. In this study, the sialorrhea reporting patterns of clozapine compared with other antipsychotics were assessed by evaluating differences in relative reporting frequency and reporter type.