Open AccessThe Relationship Between Cumulative Exogenous Corticosteroid Exposure and Volumes of Hippocampal Subfields and Surrounding Structures
Author(s) -
Duc T. Nguyen,
Michael A. Yassa,
Nicholas J. Tustison,
Jared M. Roberts,
Alexandra Kulikova,
Alyson Nakamura,
Elena I. Ivleva,
Erin Van Enkevort,
E. Sherwood Brown
Publication year - 2019
Publication title -
journal of clinical psychopharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.786
H-Index - 121
eISSN - 1533-712X
pISSN - 0271-0749
DOI - 10.1097/jcp.0000000000001120
Subject(s) - dentate gyrus , hippocampal formation , hippocampus , prednisone , glucocorticoid , corticosterone , medicine , population , endocrinology , physiology , psychology , hormone , environmental health
Glucocorticoids are a class of hormones that include naturally occurring cortisol and corticosterone, as well as prescription drugs commonly used to manage inflammatory, autoimmune, and allergic conditions. Adverse effects, including neuropsychiatric symptoms, are common. The hippocampus appears to be especially sensitive to the effects of glucocorticoids. However, to our knowledge, no studies to date have examined hippocampal subfields in humans receiving glucocorticoids. We examined patients on chronic glucocorticoid regimens to determine relationships between dose and duration of treatment, and hippocampal subfields, and related regions volumes.