Open AccessSuppression of vacuolar-type ATPase and induction of endoplasmic reticulum stress by proton pump inhibitors
Author(s) -
WeiPing Lee
Publication year - 2022
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1097/jcma.0000000000000785
Subject(s) - endoplasmic reticulum , unfolded protein response , atf6 , medicine , tfeb , nfat , atpase , myeloid leukemia , microbiology and biotechnology , biochemistry , pharmacology , lysosome , biology , enzyme , calcineurin , transplantation
Proton pump inhibitors (PPIs), such as esomeprazole, pantoprazole, dexlansoprazole, and rabeprazole, are one of the most commonly prescribed medications. Several studies have linked the long-term use of PPIs to a potentially increased risk of gastric cancer. Therefore, this study aimed to determine the underlying mechanism of PPI-mediated gastric cancer.