Open AccessSerum levels of alpha1-antitrypsin isoforms in patients with ovarian clear cell carcinoma: An exploratory study
Author(s) -
Sung-Yao Chen,
Ting–Chang Chang,
Chiao-Yun Lin,
Chia-Yun Lai,
RenChin Wu,
LanYan Yang,
WeiYang Chang,
YunShien Lee,
Wei Yang,
Angel Chao
Publication year - 2021
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1097/jcma.0000000000000604
Subject(s) - medicine , oncology , gene isoform , ovarian carcinoma , ovarian cancer , cancer , genetics , gene , biology
Ovarian clear cell carcinoma (OCCC) is frequently associated with endometriosis. Since serum levels of cancer antigen 125 (CA125) have limited diagnostic and prognostic value in this malignancy, there is an unmet need for reliable and specific biomarkers. Previous findings indicated that alpha 1-antitrypsin isoforms (isoAAT) are significantly increased in the peritoneal fluid of patients with endometriosis. This study was undertaken to examine whether serum isoAAT levels in patients with OCCC differ from those measured in women with endometriosis or benign ovarian tumors. We also investigated whether this biomarker may be useful for predicting survival in OCCC.