Open AccessFabrication of hyaluronic acid-gold nanoparticles with chitosan to modulate neural differentiation of mesenchymal stem cells
Author(s) -
ChiungChyi Shen,
MengYin Yang,
Kai-Bo Chang,
Chia-Hsuan Tseng,
YiPing Yang,
YiChin Yang,
MeiLang Kung,
Weiyi Lai,
Tzu-Wei Lin,
Hsien-Hsu Hsieh,
Huey-Shan Hung
Publication year - 2021
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1097/jcma.0000000000000589
Subject(s) - biocompatibility , mesenchymal stem cell , hyaluronic acid , chitosan , in vivo , nestin , fourier transform infrared spectroscopy , colloidal gold , angiogenesis , viability assay , medicine , biomedical engineering , nanoparticle , nuclear chemistry , biophysics , in vitro , materials science , nanotechnology , stem cell , neural stem cell , chemistry , biochemistry , microbiology and biotechnology , pathology , chemical engineering , cancer research , biology , anatomy , organic chemistry , engineering
Chitosan (Chi) is a natural material which has been widely used in neural applications due to possessing better biocompatibility. In this research study, a novel of nanocomposites film based on Chi with hyaluronic acid (HA), combined with varying amounts of gold nanoparticles (AuNPs), was created resulting in pure Chi, Chi-HA, Chi-HA-AuNPs (25 ppm), and Chi-HA-AuNPs (50 ppm).