Open AccessPolymorphism of rs6426749 at 1p36.12 is associated with the risk of osteoarthritis in Taiwanese female population
Author(s) -
Dung-Jang Tsai,
MingCheng Tai,
Chung-Cheng Kao,
Wei-Teing Chen,
Liwei Wu,
Chih-Chien Chiu,
Ming-Yu Tu,
YiChou Chen,
ChiaChun Wu,
Sui-Lung Su
Publication year - 2021
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1097/jcma.0000000000000515
Subject(s) - medicine , odds ratio , body mass index , confidence interval , allele , genotype , osteoarthritis , logistic regression , population , oncology , genetics , gene , pathology , biology , environmental health , alternative medicine
Osteoarthritis (OA) is a multifactorial disease that is associated with several genetic factors. TFAP2A with a motif of C allele at rs6426749 demonstrates a higher binding ability, thereby increasing CDC42 expression, potentially affecting OA occurrence. In this study, we evaluated the role of rs6426749 polymorphisms on knee OA in a female Taiwanese population.