Open AccessInterleukin-2 receptor alpha as a biomarker for nonalcoholic fatty liver disease diagnosis
Author(s) -
WeiYu Kao,
YuanFeng Lin,
IWei Chang,
ChiLong Chen,
Jui-Hsiang Tang,
ChunChao Chang,
YuJia Chang,
Weu Wang
Publication year - 2021
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1097/jcma.0000000000000469
Subject(s) - medicine , nonalcoholic fatty liver disease , odds ratio , gastroenterology , fatty liver , body mass index , fibrosis , liver biopsy , confidence interval , biopsy , disease
Two recent studies in the adult and pediatric Nonalcoholic Steatohepatitis-Clinical Research Network (NASH-CRN) cohorts have shown that soluble interleukin-2 receptor alpha (IL2RA) levels increased with fibrosis severity. However, no hepatic study has been conducted in Asian morbidly obese patients who underwent bariatric surgery. In this study, we proposed IL2RA as a biomarker for nonalcoholic fatty liver disease (NAFLD) diagnosis and performed immunohistochemistry (IHC) staining of IL2RA.