Open AccessMorphine produces better thermal analgesia in young Huntington mice and are associated with less neuroinflammation in spinal cord
Author(s) -
Yuan Yuarn Liu,
Ya Lin,
Hao-Yuan Hsiao,
Jeffery Chi Fei Wang,
Yen Chin Liu
Publication year - 2020
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1097/jcma.0000000000000448
Subject(s) - medicine , morphine , analgesic , spinal cord , huntington's disease , nociception , neuroinflammation , blot , pharmacology , anesthesia , endocrinology , inflammation , disease , biology , receptor , biochemistry , psychiatry , gene
Huntington's disease (HD) is an inherited disease characterized by both mental and motor dysfunctions. Our previous studies showed that HD mice demonstrate a diminished pain response. However, few studies have focused on the relationship between HD and morphine analgesia. The purpose of this study is to investigate and compare the analgesic effects of morphine in HD and wild-type (WT) mice.