Open AccessNanodiamond-based microRNA delivery system promotes pluripotent stem cells toward myocardiogenic reprogramming
Author(s) -
Chao Yu Liu,
Ming Cheng Lee,
Heng Fu Lin,
Yi Lin,
Wei Lai,
Yueh Chien,
Teh Ia Huo,
Wen-Liang Lo,
Yuan Tzu Lan,
Yi Wei Chen,
Pin I. Huang,
Yong Yang Liu,
Meng Yang
Publication year - 2020
Publication title -
journal of the chinese medical association
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1097/jcma.0000000000000441
Subject(s) - induced pluripotent stem cell , reprogramming , medicine , microrna , stem cell , gene delivery , regenerative medicine , cellular differentiation , embryonic stem cell , regeneration (biology) , bioinformatics , microbiology and biotechnology , cancer research , genetic enhancement , biology , cell , gene , genetics
Gene therapy is the advanced therapeutics for supplying or replacing the genetic material in patients with inherited disorders. Recent clinical studies have made some progress in a wide range of applications, including monogenic disorders, neurodegenerative diseases, malignant tumors, and congenital diseases. Heart diseases, especially myocardial ischemia, remain one of the leading causes of mortality worldwide and usually result in irreparable cardiomyocyte damage and severe heart failure.