Open AccessReverse expression of α2,6-sialic acid ratios on IgG, IgM, and IgG/IgM autoantibodies correlates with mouse arthritis and rheumatoid arthritis disease activity
Author(s) -
Lieh-Bang Liou,
Chung-Bin Huang
Publication year - 2020
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1097/jcma.0000000000000439
Subject(s) - autoantibody , medicine , antibody , rheumatoid arthritis , immunoglobulin m , immunoglobulin g , arthritis , immunology , rheumatoid factor , sialic acid , autoimmune disease , biology , biochemistry
Sialic acids (SIAs), for example, α2,6-SIAs, can link to conserved N-glycans of immunoglobulin G (IgG). In this study, we investigated the correlation between α2,6-SIA on IgG and IgM and the disease activity of arthritis and rheumatoid arthritis (RA) in mice.