Open AccessGenetic variations of three important antioxidative enzymes SOD2, CAT, and GPX1 in nonalcoholic steatohepatitis
Author(s) -
Yo-Ping Huang,
Tsung-Hsien Chang,
Cherng-Kang Perng,
Yi-Hsiang Huang
Publication year - 2020
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1097/jcma.0000000000000437
Subject(s) - sod2 , gpx1 , genotype , allele , minor allele frequency , medicine , superoxide dismutase , glutathione peroxidase , allele frequency , biology , endocrinology , genetics , gene , oxidative stress
Nonalcoholic steatohepatitis (NASH) is closely related to reactive oxygen species (ROS). Superoxide anion radicals, the main product of ROS, can be reduced by manganese superoxide dismutase (SOD2) to hydrogen peroxide, which is further reduced by catalase (CAT) and glutathione peroxidase (GPX) to water. We aimed to investigate the association between the most important genetic variants of SOD2, CAT, and GPX1 and susceptibility to NASH.