Open AccessMicro-RNA-183-5p acts as a potential diagnostic biomarker for atherosclerosis and regulates the growth of vascular smooth muscle cell
Author(s) -
Bin Sun,
Zhengkun Shan,
Guoyu Sun,
Xiaolong Wang
Publication year - 2020
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1097/jcma.0000000000000433
Subject(s) - vascular smooth muscle , biomarker , medicine , microrna , cell growth , cancer research , cell , receiver operating characteristic , diagnostic biomarker , cell migration , pathology , microbiology and biotechnology , smooth muscle , gene , diagnostic accuracy , biology , biochemistry
Atherosclerosis (AS) is a multifactorial chronic disease, and vascular smooth muscle cells (VSMCs) play important roles in the pathology of AS. Micro-RNAs regulate multiple cellular biological processes. This study aimed to investigate the clinical value of miR-183-5p in AS patients and further explored the effects of miR-183-5p on the proliferation and migration of VSMCs.