Open AccessDesflurane protects against liver ischemia/reperfusion injury via regulating miR-135b-5p
Author(s) -
Mengxia Zhong,
Lei Che,
Min Du,
Ke Liu,
Dalong Wang
Publication year - 2020
Publication title -
journal of the chinese medical association
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1097/jcma.0000000000000427
Subject(s) - desflurane , medicine , liver injury , western blot , reperfusion injury , apoptosis , pharmacology , transaminase , alanine transaminase , aspartate transaminase , anesthesia , endocrinology , ischemia , biochemistry , chemistry , gene , sevoflurane , enzyme , alkaline phosphatase
A number of anesthetics have protective effect against ischemia-reperfusion (I/R) injury, including desflurane. But the function and molecular mechanism of desflurane in liver I/R injury have not been fully understood. The aim of this study was to investigate the effect of desflurane on liver I/R injury and further investigated the molecular mechanisms involving in miR-135b-5p.