Open AccessDownregulation of lncRNA UCA1 facilitates apoptosis and reduces proliferation in multiple myeloma via regulation of the miR-1271-5p/HGF axis
Author(s) -
Yi Yang,
Lin Chen
Publication year - 2019
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1097/jcma.0000000000000145
Subject(s) - downregulation and upregulation , apoptosis , flow cytometry , cell growth , cancer research , hepatocyte growth factor , in vivo , microrna , cell culture , cell , long non coding rna , microbiology and biotechnology , medicine , biology , gene , biochemistry , receptor , genetics
Long noncoding RNAs (lncRNAs) are considered to be a novel prognostic and therapeutic target in many cancers. This study identified dysregulation of lncRNA urothelial carcinoma associated 1 (UCA1) and hepatocyte growth factor (HGF) mRNA via the Gene Expression Omnibus (GEO) database, which was traced to the mutual target miRNA, miR-1271-5p, and their effects were explored in multiple myeloma (MM).