Open AccessAntitumor and off-target effects of cholesterol-conjugated let-7a mimics in an orthotopic hepatocellular carcinoma xenograft nude mouse model
Author(s) -
Jian Guan,
Mingyang Li,
Xin Li,
Liangrui Zhou,
Xixuan Dong,
Wei Dai,
Yu Xia,
Tao Yang,
Shaojuan Guo,
Xingqi Li,
Yehua Han,
Yousong Luo
Publication year - 2022
Publication title -
journal of bio-x research/journal of bio-x research
Language(s) - English
Resource type - Journals
eISSN - 2096-5672
pISSN - 2577-3585
DOI - 10.1097/jbr.0000000000000103
Subject(s) - in vivo , hepatocellular carcinoma , medicine , pathology , cancer research , chemistry , biology , microbiology and biotechnology
To explore the antitumor and potential off-target effects of systemically delivered cholesterol-conjugated let-7a mimics (Chol-let-7a ) and control mimics (Chol-miRCtrl ) on hepatocellular carcinoma in vivo.