Open AccessDifferential Profiles and Inhibitory Effect on Rotavirus Vaccines of Nonantibody Components in Breast Milk From Mothers in Developing and Developed Countries
Author(s) -
Sung-Sil Moon,
Jacqueline E. Tate,
Pratima Ray,
Penelope Dennehy,
Derseree Archary,
Anna Coutsoudis,
Ruth Bland,
Marie-Louìse Newell,
Roger I. Glass,
Umesh D. Parashar,
Baoming Jiang
Publication year - 2013
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e318290646d
Subject(s) - lactoferrin , rotavirus , titer , rotavirus vaccine , medicine , breast milk , virology , immunology , biology , virus , biochemistry , genetics
Live oral rotavirus vaccines have been less immunogenic and efficacious for children of developing countries than for those in middle income and industrialized countries, and the basis for these differences is not fully understood. Recently, we demonstrated that breastmilk from mothers in India had significantly higher IgA and neutralizing activity against rotavirus that could reduce the effective titer of rotavirus vaccines reaching the gut when compared with that from mothers in the United States. We extended our study to understand the specific contribution of those nonantibody components in breastmilk to the neutralizing activity against rotavirus vaccine we observed.