Evaluation of IgG Anti-Toxoplasma Avidity and Polymerase Chain Reaction in the Postnatal Diagnosis of Congenital Toxoplasmosis | Zendy

Elizabeth Torres | Zendy; Raúl Rivera | Zendy; Néstor Cardona | Zendy; Víctor Sánchez | Zendy; Fabiana Lora | Zendy; Jorge Enrique GómezMarín | Zendy

Open Access

Evaluation of IgG Anti-Toxoplasma Avidity and Polymerase Chain Reaction in the Postnatal Diagnosis of Congenital Toxoplasmosis

Author(s) -

Elizabeth Torres,

Raúl Rivera,

Néstor Cardona,

Víctor Sánchez,

Fabiana Lora,

Jorge Enrique GómezMarín

Publication year - 2013

Publication title -

the pediatric infectious disease journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.028

H-Index - 140

eISSN - 1532-0987

pISSN - 0891-3668

DOI - 10.1097/inf.0b013e31828807a4

Subject(s) - avidity , polymerase chain reaction , toxoplasmosis , congenital toxoplasmosis , immunology , real time polymerase chain reaction , virology , antibody , medicine , biology , toxoplasma gondii , genetics , gene

Confirmatory tests for congenital toxoplasmosis were evaluated in 23 infected and 31 uninfected newborns. Conventional polymerase chain reaction was better than real-time polymerase chain reaction, but did not identify additional cases. Avidity tests added 2 new cases that were not identified by other criteria. Overall sensitivity was 82.6%. Avidity assay, but not polymerase chain reaction, increased the sensitivity of confirmatory assays in congenital toxoplasmosis.

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