Open AccessEvaluation of IgG Anti-Toxoplasma Avidity and Polymerase Chain Reaction in the Postnatal Diagnosis of Congenital Toxoplasmosis
Author(s) -
E. Morales,
Raúl Rivera,
Néstor Cardona,
Víctor Sánchez,
Fabiana Lora,
Jorge Enrique GómezMarín
Publication year - 2013
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e31828807a4
Subject(s) - avidity , polymerase chain reaction , toxoplasmosis , congenital toxoplasmosis , immunology , real time polymerase chain reaction , virology , antibody , medicine , biology , toxoplasma gondii , genetics , gene
Confirmatory tests for congenital toxoplasmosis were evaluated in 23 infected and 31 uninfected newborns. Conventional polymerase chain reaction was better than real-time polymerase chain reaction, but did not identify additional cases. Avidity tests added 2 new cases that were not identified by other criteria. Overall sensitivity was 82.6%. Avidity assay, but not polymerase chain reaction, increased the sensitivity of confirmatory assays in congenital toxoplasmosis.