Group A Streptococcus Colonies From a Single Throat Swab Can Have Heterogeneous Antimicrobial Susceptibility Patterns | Zendy

Aurélie Vandevoorde | Zendy; Sabrina Ascenzo | Zendy; Véronique Yvette Miendje Deyi | Zendy; Georges Mascart | Zendy; Anne-Laure Mansbach | Zendy; Marguerite Landsberg | Zendy; Pierre Luc Dreze | Zendy; Andrew C. Steer | Zendy; Laurence Van Melderen | Zendy; Pierre R. Smeesters | Zendy

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Group A Streptococcus Colonies From a Single Throat Swab Can Have Heterogeneous Antimicrobial Susceptibility Patterns

Author(s) -

Aurélie Vandevoorde,

Sabrina Ascenzo,

Véronique Yvette Miendje Deyi,

Georges Mascart,

Anne-Laure Mansbach,

Marguerite Landsberg,

Pierre Luc Dreze,

Andrew C. Steer,

Laurence Van Melderen,

Pierre R. Smeesters

Publication year - 2012

Publication title -

the pediatric infectious disease journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.028

H-Index - 140

eISSN - 1532-0987

pISSN - 0891-3668

DOI - 10.1097/inf.0b013e31827c9796

Subject(s) - pharyngitis , throat , antibiotics , medicine , microbiology and biotechnology , antibiotic resistance , antimicrobial , streptococcaceae , streptococcus , genotype , group a , throat culture , acute pharyngitis , streptococcus pneumoniae , biology , bacteria , gene , genetics , surgery

This study describes for the first time heterogeneity of antibiotic resistance profiles among group A Streptococcus isolates originating from a single throat swab in patients with acute pharyngitis. For each throat swab, 10 group A Streptococcus colonies were randomly selected from the primary plate and subcultured to a secondary plate. These isolates were characterized by various phenotypic and genotypic methods. Our results demonstrated that differing antibiotic resistance profiles were present in 19% of pediatric patients with acute pharyngitis before antimicrobial treatment. This heterogeneity likely resulted from horizontal gene transfer among streptococcal isolates sharing the same genetic background. As only a minority of colonies displayed antibiotic resistance among these heterogeneous samples, a classical diagnostic antibiogram would have classified them in most instances as "susceptible," although therapeutic failure could be caused by the proliferation of resistant strains after initiation of antibiotic treatment.

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