Open AccessT-Cell Responses in Children to Internal Influenza Antigens, 1 Year After Immunization With Pandemic H1N1 Influenza Vaccine, and Response to Revaccination With Seasonal Trivalent–inactivated Influenza Vaccine
Author(s) -
Teresa Lambe,
Alexandra J. Spencer,
Caitlin E. Mullarkey,
Richard Antrobus,
Ly-Mee Yu,
P de Whalley,
Ben Thompson,
Claire Jones,
Jem Chalk,
Simon Kerridge,
Hill Avs.,
Matthew D. Snape,
Andrew J. Pollard,
Sarah C. Gilbert
Publication year - 2012
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e318255e443
Subject(s) - vaccination , medicine , virology , live attenuated influenza vaccine , influenza vaccine , immunology , immunization , pandemic , reactogenicity , immunogenicity , antigen , influenza a virus , virus , disease , covid-19 , infectious disease (medical specialty)
During seasonal influenza epidemics, 5-15% of the population are affected with an illness having a nontrivial mortality, morbidity and economic burden. Inactivated influenza vaccines are routinely used to prevent influenza infection, primarily by inducing humoral immunity. In addition, trivalent-inactivated influenza vaccines have previously been shown to boost influenza-specific T-cell responses in a small percentage of adults. We investigate here the influenza-specific T-cell response, in children, 1 year after pandemic H1N1 vaccination and the ability to boost the T-cell response with trivalent-inactivated influenza immunization.