Open AccessLinezolid and Lactic Acidosis
Author(s) -
Erik Su,
Kelli Crowley,
Joseph A. Carcillo,
Marian G. Michaels
Publication year - 2011
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e3182186035
Subject(s) - lactic acidosis , medicine , linezolid , acidosis , toxicity , intensive care medicine , anesthesia , bacteria , staphylococcus aureus , biology , vancomycin , genetics
Linezolid administration has been associated with lactic acidosis in adults; however, the same phenomenon has not been reported in children. Mitochondrial protein synthesis inhibition is a demonstrated mechanism for toxicity, which therefore may manifest as lactic acidosis. Three cases of linezolid-associated lactic acidosis in children are reported to reinforce the need for pediatric caregivers to be vigilant of this potential side effect.