Open AccessIMMEDIATE AND LONGER TERM IMMUNOGENICITY OF A SINGLE DOSE OF THE COMBINED HAEMOPHILUS INFLUENZAE TYPE B-NEISSERIA MENINGITIDIS SEROGROUP C-TETANUS TOXOID CONJUGATE VACCINE IN PRIMED TODDLERS 12 TO 18 MONTHS OF AGE
Author(s) -
Robert Booy,
Peter Richmond,
Terry Nolan,
Jodie McVer,
Helen Marshall,
Michael D. Nissen,
Graham Reynolds,
John B. Ziegler,
Leon Heron,
Stephen B. Lambert,
Magalie Caubet,
Narcisa Mesaros,
Dominique Boutriau
Publication year - 2011
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e31820013d2
Subject(s) - immunogenicity , medicine , toxoid , conjugate vaccine , neisseria meningitidis , tetanus , titer , haemophilus influenzae , pediatrics , antibody , immunology , vaccination , virology , microbiology and biotechnology , biology , antibiotics , bacteria , genetics
Hib-primed but MenC-naive toddlers (N = 433) were randomized to receive 1 dose of Hib-MenC-TT or separate Hib-TT and MenC-CRM197 vaccines. One month later, noninferiority was demonstrated for serum bactericidal anti-MenC antibodies (rSBA) and Hib antipolyribosylribitol phosphate (PRP) antibodies; >99% in both groups had rSBA titer ≥ 8 or anti-PRP concentration ≥ 0.15 μg/mL. After 12 months, rSBA titer ≥ 8 persisted in 86.7% and 76.4%, and anti-PRP concentration ≥ 0.15 μg/mL persisted in 98.8% and 100% of children, respectively.