LACK OF ASSOCIATION OF KAWASAKI DISEASE AFTER IMMUNIZATION IN A COHORT OF INFANTS FOLLOWED FOR MULTIPLE AUTOIMMUNE DIAGNOSES IN A LARGE, PHASE-4 OBSERVATIONAL DATABASE SAFETY STUDY OF 7-VALENT PNEUMOCOCCAL CONJUGATE VACCINE | Zendy

Kimberly J. Center | Zendy; John Hansen | Zendy; Edwin Lewis | Zendy; Bruce Fireman | Zendy; Betsy Hilton | Zendy

Open Access

LACK OF ASSOCIATION OF KAWASAKI DISEASE AFTER IMMUNIZATION IN A COHORT OF INFANTS FOLLOWED FOR MULTIPLE AUTOIMMUNE DIAGNOSES IN A LARGE, PHASE-4 OBSERVATIONAL DATABASE SAFETY STUDY OF 7-VALENT PNEUMOCOCCAL CONJUGATE VACCINE

Author(s) -

Kimberly J. Center,

John Hansen,

Edwin Lewis,

Bruce Fireman,

Betsy Hilton

Publication year - 2009

Publication title -

the pediatric infectious disease journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.028

H-Index - 140

eISSN - 1532-0987

pISSN - 0891-3668

DOI - 10.1097/inf.0b013e318196934a

Subject(s) - medicine , kawasaki disease , observational study , pneumococcal conjugate vaccine , pediatrics , confounding , immunization , cohort study , medical diagnosis , streptococcus pneumoniae , immunology , antibiotics , pathology , artery , antigen , microbiology and biotechnology , biology

A large-scale, postmarketing observational database safety study was conducted following 7-valent pneumococcal conjugate vaccine (PCV7) licensure. A secondary outcome was the occurrence of predefined diagnoses among PCV7 vaccinees versus historic controls. Forty-two PCV7 recipients and 17 controls were hospitalized for Kawasaki disease (P = 0.012). After adjusting for potential confounding variables, this difference was not significant (P = 0.083). No association between Kawasaki disease and PCV7 was found.

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