Open AccessLACK OF ASSOCIATION OF KAWASAKI DISEASE AFTER IMMUNIZATION IN A COHORT OF INFANTS FOLLOWED FOR MULTIPLE AUTOIMMUNE DIAGNOSES IN A LARGE, PHASE-4 OBSERVATIONAL DATABASE SAFETY STUDY OF 7-VALENT PNEUMOCOCCAL CONJUGATE VACCINE
Author(s) -
Kimberly J. Center,
John Hansen,
Edwin Lewis,
Bruce Fireman,
Betsy Hilton
Publication year - 2009
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e318196934a
Subject(s) - medicine , kawasaki disease , observational study , pneumococcal conjugate vaccine , pediatrics , confounding , immunization , cohort study , medical diagnosis , streptococcus pneumoniae , immunology , antibiotics , pathology , artery , antigen , microbiology and biotechnology , biology
A large-scale, postmarketing observational database safety study was conducted following 7-valent pneumococcal conjugate vaccine (PCV7) licensure. A secondary outcome was the occurrence of predefined diagnoses among PCV7 vaccinees versus historic controls. Forty-two PCV7 recipients and 17 controls were hospitalized for Kawasaki disease (P = 0.012). After adjusting for potential confounding variables, this difference was not significant (P = 0.083). No association between Kawasaki disease and PCV7 was found.