Open AccessAn Elevated Value of High Mobility Group Box 1 is a Potential Marker for Poor Response to High-Dose of Intravenous Immunoglobulin Treatment in Patients With Kawasaki Syndrome
Author(s) -
Takashi Eguchi,
Yoshio Nomura,
Teruto Hashiguchi,
Kiminori Masuda,
Michiko Arata,
Daisuke Hazeki,
Koichi Ueno,
Junichiro Nishi,
Yoshifumi Kawano,
Ikuro Maruyama
Publication year - 2009
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e31818ffe60
Subject(s) - medicine , hmgb1 , kawasaki disease , lactate dehydrogenase , antibody , gastroenterology , receiver operating characteristic , white blood cell , immunology , inflammation , biochemistry , chemistry , artery , enzyme
We examined the serum values of high mobility group box 1 (HMGB1) in 36 patients with Kawasaki syndrome (KS) (29 responders and 7 poor-responders to initial intravenous immunoglobulin treatment). A mean value of HMGB1 of poor-responders was significantly elevated compared with those of responders (P = 0.0042). Among the 6 factors showing significant differences between responders and poor-responders including HMGB1 (admission illness day, white blood cell counts, C-reactive protein, aspartate aminotransferase, lactate dehydrogenase), values of HMGB1 showed the widest area under the receiver operating characteristic curve. In conclusion, an elevated HMGB1 value could be a potential marker for poor-responders.