Open AccessINFUSION OF CYTOMEGALOVIRUS SPECIFIC CYTOTOXIC T LYMPHOCYTES FROM A SERO-NEGATIVE DONOR CAN FACILITATE RESOLUTION OF INFECTION AND IMMUNE RECONSTITUTION
Author(s) -
Biljana Horn,
Lei Bao,
Kimberly Dunham,
Mindy Stamer,
Stuart P. Adler,
Morton J. Cowan,
Kenneth G. Lucas
Publication year - 2009
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e318182026f
Subject(s) - viremia , medicine , ctl* , cytotoxic t cell , cytomegalovirus , immunology , virology , betaherpesvirinae , immune system , refractory (planetary science) , cytomegalovirus infection , human cytomegalovirus , stem cell , herpesviridae , viral disease , virus , biology , cd8 , in vitro , biochemistry , genetics , astrobiology
We report a stem cell transplant patient with a therapy-refractory cytomegalovirus (CMV) infection who received CMV-specific T cells from his sero-negative stem cell donor. This donor received the Towne strain CMV vaccine, and T cells were expanded using monocytes pulsed with pp65 overlapping peptides. CMV DNA decreased after the CTL infusion, and CMV-specific cytotoxicity increased. This strategy could be implemented in similar situations or with persistent viremia post-transplant.