INFUSION OF CYTOMEGALOVIRUS SPECIFIC CYTOTOXIC T LYMPHOCYTES FROM A SERO-NEGATIVE DONOR CAN FACILITATE RESOLUTION OF INFECTION AND IMMUNE RECONSTITUTION | Zendy

Biljana Horn | Zendy; Lei Bao | Zendy; Kimberly Dunham | Zendy; Mindy Stamer | Zendy; Stuart P. Adler | Zendy; Morton J. Cowan | Zendy; Kenneth G. Lucas | Zendy

Open Access

INFUSION OF CYTOMEGALOVIRUS SPECIFIC CYTOTOXIC T LYMPHOCYTES FROM A SERO-NEGATIVE DONOR CAN FACILITATE RESOLUTION OF INFECTION AND IMMUNE RECONSTITUTION

Author(s) -

Biljana Horn,

Lei Bao,

Kimberly Dunham,

Mindy Stamer,

Stuart P. Adler,

Morton J. Cowan,

Kenneth G. Lucas

Publication year - 2008

Publication title -

the pediatric infectious disease journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.028

H-Index - 140

eISSN - 1532-0987

pISSN - 0891-3668

DOI - 10.1097/inf.0b013e318182026f

Subject(s) - viremia , medicine , ctl* , cytotoxic t cell , cytomegalovirus , immunology , virology , betaherpesvirinae , immune system , refractory (planetary science) , cytomegalovirus infection , human cytomegalovirus , stem cell , herpesviridae , viral disease , virus , biology , cd8 , in vitro , biochemistry , genetics , astrobiology

We report a stem cell transplant patient with a therapy-refractory cytomegalovirus (CMV) infection who received CMV-specific T cells from his sero-negative stem cell donor. This donor received the Towne strain CMV vaccine, and T cells were expanded using monocytes pulsed with pp65 overlapping peptides. CMV DNA decreased after the CTL infusion, and CMV-specific cytotoxicity increased. This strategy could be implemented in similar situations or with persistent viremia post-transplant.

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