Open AccessDECLINE IN PNEUMOCOCCAL MENINGITIS IN SPAIN AFTER INTRODUCTION OF THE HEPTAVALENT PNEUMOCOCCAL CONJUGATE VACCINE
Author(s) -
Juan CasadoFlores,
Rodrigo Corrêa-Oliveira,
Javier Arı́stegui,
José María Martinón,
Asunción Fenoll,
Cristina Méndez
Publication year - 2008
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e31817bd2dc
Subject(s) - medicine , meningitis , incidence (geometry) , case fatality rate , pneumococcal conjugate vaccine , streptococcus pneumoniae , pediatrics , serotype , immunology , virology , epidemiology , antibiotics , microbiology and biotechnology , physics , optics , biology
All patients < or =14 years old with a diagnosis of pneumococcal meningitis (n = 160) were included (2001, 2004-2006). Incidence per 100,000 child <5 years old varied from 6.14 in 2001 to 2.83 in 2006 (54% of reduction, P < 0.01). There was a significant correlation (R2 = 0.9506) with PCV7 distribution increase. No significant changes in the incidence by nonvaccine serotypes were found when comparing 2001 and 2006. The case fatality rate was 7.5%.