Open AccessCOVID-19 in Children: Correlation Between Epidemiologic, Clinical Characteristics, and RT-qPCR Cycle Threshold Values
Author(s) -
Ángela Gentile,
María Del Valle Juárez,
María Florencia Luciön,
María Natalia Pejito,
Sofía Alexay,
Ana S Orqueda,
Lucía Romero Bollón,
Alicia Mistchenko
Publication year - 2022
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000003564
Subject(s) - interquartile range , medicine , asymptomatic , covid-19 , epidemiology , viral load , pediatrics , gastroenterology , immunology , disease , virus , infectious disease (medical specialty)
Initially, the impact of SARS-CoV-2 infection on children was unknown. Standard COVID-19 diagnosis is confirmed using real-time qPCR. Cycle threshold (Ct) values of RT-qPCR are inversely proportional to viral load and the test indirectly quantifies viral RNA copy numbers. The objective of this study was to determine the correlation between epidemiology, clinical characteristics, severity of confirmed COVID-19 cases, and Ct values.