Open AccessDo Rotavirus Strains Affect Vaccine Effectiveness? A Systematic Review and Meta-analysis
Author(s) -
Jordan Cates,
Avnika B. Amin,
Jacqueline E. Tate,
Ben Lopman,
Umesh D. Parashar
Publication year - 2021
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000003286
Subject(s) - rotavirus , rotavirus vaccine , meta analysis , confidence interval , diarrhea , strain (injury) , vaccine efficacy , pooled analysis , vaccination , medicine , virology , immunology , biology
Rotavirus causes 215,000 deaths from severe childhood diarrhea annually. Concerns exist that a monovalent vaccine (RV1) and a pentavalent vaccine (RV5) may be less effective against rotavirus strains not contained in the vaccines. We estimated the vaccine effectiveness (VE) of RV1 and RV5 against severe rotavirus gastroenteritis caused by vaccine (homotypic) and nonvaccine (partially and fully heterotypic) strains.